Our specific question here wants to know what atoms on tyrosine are exchanged for this phosphate group on ATP. The tyrosine kinase receptor transfers phosphate groups from ATP to tyrosine molecules. A kinase is an enzyme that catalyzes the transfer of phosphate groups, and the tyrosine kinase receptor specifically is an example of a receptor enzyme. The author specifically tells us JAK2 is a tyrosine kinase. Answer choice C is our best answer choice.Ģ) This is a passage-based question and we can focus specifically on Paragraph 2 where the author talks about phosphorylation of STAT5b proteins: This is going to be the opposite function of what we’re looking for. While cytochrome P450 itself is reduced, the enzymes function to alter the activity of drugs by oxidizing them. Cytochrome P450 alters the activity of drugs by acting as an oxidizing agent to allow drugs and toxins to be metabolized. When the body detects a new drug/toxin or increased concentrations of a drug, the body increases the concentration of cytochrome P450 to metabolize the drug effectively. Cytochrome P450 enzymes function as monooxygenases. This answer choice matches our breakdown of the question and the cytochrome P450 enzyme background information we went over. This answer choice is describing phosphatases which function to dephosphorylate. We mentioned in our breakdown that we’re looking for an answer choice that deals with redox reactions. Typically, kinases will be the ones phosphorylating proteins in the body. We want an answer choice that deals with redox reactions. They are membrane-bound proteins that enable oxidation reactions. The author introduces cytochrome P450 enzymes in Paragraph 3 and we get some background information:Ĭytochrome p450 enzymes appear a few times in AAMC’s practice material but it’s not explicitly listed on the content outline. 1) This is a passage-related question that functions almost like a pseudo-discrete.
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